Saving the Day

The fine print on my t-shirt says, “RNA Saves the Day.” I bought the shirt almost three years ago, to celebrate my trips to the Texas Motor Speedway for my first two COVID shots.

But here we are three years later, with vaccine misinformation still percolating through the population. Most recently, the State Surgeon General of Florida warned against mRNA vaccines, claiming the vaccines are contaminated with DNA fragments.

Know what else is “contaminated” with harmless DNA fragments? The food you eat.

Even before their release, alarmists were pre-refusing the mRNA vaccines: It’s too fast! No one wants an experimental vaccine!

Just for fun, let’s look at what was happening in the before-times, the years before covid flipped our world.

In the days before shutdowns and paper towel shortages, researchers were knee-deep investigating the use of mRNA in treating a myriad of diseases. Of particular interest were diseases caused by inborn metabolic errors.

For example, people born with a glycogen storage disease do not make the protein needed to release sugar from storage between meals. If these people do not eat every hour or two (including all through the night), they risk life-threatening low blood sugar.

What if mRNA could be used to teach the body to produce the missing protein? Researchers were on it.

Already mRNA was being injected directly into heart muscle during open-heart surgery, instructing the heart to build new vessels to circumvent clogged arteries.

And personalized cancer treatments using mRNA had an astounding turn-around of 45 days from development to patient.

So, when the genetic sequence of the COVID virus was published in January 2020, it only took two days for vaccine scientists to decide which of the COVID spikes to target.

One hour – that’s all it took to design the mRNA for the spike used in the vaccines. Forty-five days later, the NIH began vaccine development.

It wasn’t speedy because scientists were careless. It was speedy because they weren’t starting from scratch.

And research hasn’t stopped.

In a clinical trial of melanoma patients, one group was given Moderna’s mRNA melanoma therapy along with a biologic that enhances immune response. Another group was given the biologic alone.

Three years after treatment, patients who received the mRNA therapy in addition to the biologic saw a 49% reduction in the risk of melanoma recurrence or death and a 62% reduction in the risk of metastasis or death compared to those who received only the biologic .

That’s huge.

Saving the day, indeed.

COVID Vaccines: The Fast and the Furious

COVID Vaccines: The Fast and the Furious

They said it was “experimental.”

They said it was developed too fast, that it was “rushed.”

They said it was a political move by bureaucratic government scientists, and Anthony Fauci was the archvillain.

They even said it was a monstrosity that would change your DNA, make you infertile, and give Bill Gates microchip control over a population of “sheeple.”

Today, hundreds of thousands of people owe their lives to a COVID vaccine using mRNA technology – technology that has been studied and refined since the 1980s.

Molecular biologist Katalin Karikó was convinced that mRNA could revolutionize vaccine delivery. For almost a decade, Dr. Karikó worked in obscurity. 

A chance meeting with immunologist Drew Weissman at the University of Pennsylvania changed history.

It was 1998. Karikó and Weissman were chatting at the copy machine, waiting for it to warm up. Thus began a partnership with the goal of using mRNA to deliver a safe and revolutionary vaccine. 

Karikó and Weissman first published their groundbreaking discoveries in 2005. For the next fifteen years, they continue to work and publish with little funding.

But two biotech companies, Moderna and BioNTech, noticed. 

And in 2020, with a deadly pandemic looming, these companies combined the years of coronavirus research being done at the NIH and other labs with the work of Karikó and Weissman to produce two COVID-19 vaccines, each using mRNA technology.

Today, FOUR DECADES of research later, the Nobel Prize in Medicine or Physiology was awarded to Katalin Karikó and Drew Weissman. 

Congratulations and well-done from a grateful world.